Palazzo de Mori is an ancient and noble multi-storey residence, located on the ramparts in the historic centre of Otranto, a stone's throw from the small Byzantine church of San Pietro, the Aragonese Castle and the Cathedral known for its marvellous mosaics.

The old mansion originally belonged to the Leondari family, after whom the old street leading to it, through the embroidery of the narrow streets of Otranto's historic centre, was named.